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Oxidative stress and TGF-ß1 induction by metformin in MCF-7 and MDA-MB-231 human breast cancer cells are accompanied with the downregulation of genes related to cell proliferation, invasion and metastasis.
Marinello, Poliana C; Panis, Carolina; Silva, Thamara N X; Binato, Renata; Abdelhay, Eliana; Rodrigues, Juliana A; L Mencalha, André; Lopes, Natália M D; Borges, Fernando H; Luiz, Rodrigo C; Cecchini, Rubens; Cecchini, Alessandra L.
Afiliação
  • Marinello PC; Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil.
  • Panis C; Laboratory of Tumor Biology, State University of West Paraná (Unioeste), Francisco Beltrão, PR, Brazil.
  • Silva TNX; Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil.
  • Binato R; Stem Cell Laboratory, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil.
  • Abdelhay E; Stem Cell Laboratory, Bone Marrow Transplantation Unit, National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil.
  • Rodrigues JA; Laboratory of Cancer Biology, Department of Biophysics and Biometrics, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.
  • L Mencalha A; Laboratory of Cancer Biology, Department of Biophysics and Biometrics, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.
  • Lopes NMD; Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil.
  • Borges FH; Laboratory of Pathophysiology and Free Radicals, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil.
  • Luiz RC; Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil.
  • Cecchini R; Laboratory of Pathophysiology and Free Radicals, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil.
  • Cecchini AL; Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil. Electronic address: alcecchini@uel.br.
Pathol Res Pract ; 216(10): 153135, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32853957
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Movimento Celular / Estresse Oxidativo / Proliferação de Células / Fator de Crescimento Transformador beta1 / Metformina Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Movimento Celular / Estresse Oxidativo / Proliferação de Células / Fator de Crescimento Transformador beta1 / Metformina Idioma: En Ano de publicação: 2020 Tipo de documento: Article