Penctrimertone, a bioactive citrinin dimer from the endophytic fungus Penicillium sp. T2-11.
Fitoterapia
; 146: 104711, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32860875
ABSTRACT
Penctrimertone (1), a novel citrinin dimer bearing a 6/6/6/6 tetracyclic ring scaffold, along with two known compounds xerucitrinic acid A (2) and citrinin (3) were isolated from the endophytic fungus Penicillium sp. T2-11. Their structures were unequivocally established by a comprehensive interpretation of the spectroscopic data, with the stereochemistry for 1 was defined by a combination of TDDFT-ECD calculations and the DP4+ probability analysis based on NMR chemical shift calculations. Bioassays revealed that compound 1 exhibited noticeable antimicrobial activities and moderate cytotoxicity. A plausible biosynthetic pathway of 1 was also proposed.
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Base de dados:
MEDLINE
Assunto principal:
Penicillium
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Citrinina
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Gastrodia
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Antibacterianos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article