Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.
Arch Cardiovasc Dis
; 113(8-9): 572-578, 2020.
Article
em En
| MEDLINE
| ID: mdl-32863157
ABSTRACT
Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this review, we summarise the biology of this enzyme, which plays a key role in cardiovascular homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensin-converting enzyme 2 are reviewed, and the consequences of these treatments for the severity of coronavirus disease 2019 infection are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
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Sistema Renina-Angiotensina
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Inibidores da Enzima Conversora de Angiotensina
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Infecções por Coronavirus
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Bloqueadores do Receptor Tipo 1 de Angiotensina II
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Pandemias
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Betacoronavirus
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article