Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay.
Hippocampus
; 30(11): 1228-1238, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32870537
ABSTRACT
To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory-gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Região CA2 Hipocampal
/
Região CA3 Hipocampal
/
Inibição Neural
/
Plasticidade Neuronal
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article