Comparison of foveal optical coherence tomography angiography findings between premature children with ROP and non-premature healthy children.
Eye (Lond)
; 35(6): 1721-1729, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-32873943
ABSTRACT
PURPOSE:
Our aim is to compare foveal microvascular structure, foveal retinal thickness, and best-corrected visual acuity (BCVA) in children with a history of premature retinopathy (ROP) and healthy children. It is also evaluated whether microvascular structural changes in the course of ROP had resulted from treatment modalities of ROP or the disease itself.METHODS:
This is a cross-sectional observational comparative study. Seventy-one children were analyzed in four different groups children treated with bevacizumab (18), or laser (19) for ROP; or spontaneously regressed disease (18) and non-premature healthy children (16). We analyzed foveal avascular zone (FAZ) and vessel densities (VDs) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) at foveal and parafoveal region with optical coherence tomography angiography (OCT-A). Foveal thickness was measured by cross-sectional OCT. Correlations between FAZ area, foveal VD, central foveal thickness (CFT), BCVA, gestational age (GA), and birth weight (BW) were evaluated.RESULTS:
After comparing of OCT-A parameters between all premature children (groups 1-3) and non-premature children (group 4), significant differences were found in VD-SCP (whole), VD-SCP (foveal), VD-SCP (parafoveal), CFT, and VD-DCP (foveal) (all p < 0.001). Significantly smaller FAZ area was also noted in ROP children. Higher foveal VD of SCP, DCP, and smaller FAZ area were significantly associated with lower GA and BW.CONCLUSION:
By using OCT-A, significant foveal microvascular anomalies were identified in children with ROP irrespective of the treatment option or spontaneous regression. There has been a correlation between microvascular anomalies, CFT, and a lower BCVA.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vasos Retinianos
/
Tomografia de Coerência Óptica
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article