A self-immobilizing near-infrared fluorogenic probe for sensitive imaging of extracellular enzyme activity in vivo.
Chem Sci
; 11(23): 5889-5894, 2020 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-32874510
ABSTRACT
Reported herein is a self-immobilizing near-infrared fluorogenic probe that can be used to image extracellular enzyme activity in vivo. Using a fluorophore as a quinone methide precursor, this probe covalently anchors at sites of activation and greatly enhances the fluorescence intensity at 710 nm upon enzymatic stimulus, significantly boosting detection sensitivity in a highly dynamic in vivo system.
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MEDLINE
Idioma:
En
Ano de publicação:
2020
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Article