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Methylphenidate treatment of adult ADHD patients improves the degree of ADHD severity under routine conditions.
Retz, Wolfgang; Rösler, Michael; Fischer, Roland; Ose, Claudia; Ammer, Richard.
Afiliação
  • Retz W; Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Mainz, Mainz, Germany.
  • Rösler M; Institut für Gerichtliche Psychologie und Psychiatrie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Germany.
  • Fischer R; MEDICE Arzneimittel Pütter GmbH & Co. KG, Iserlohn, Germany.
  • Ose C; Institut für Medizinische Informatik, Zentrum für Klinische Studien Essen, Universitätsklinikum Essen, Biometrie und Epidemiologie, Essen, Germany.
  • Ammer R; MEDICE Arzneimittel Pütter GmbH & Co. KG, Iserlohn, Germany. richard.ammer@ukmuenster.de.
J Neural Transm (Vienna) ; 127(10): 1427-1434, 2020 10.
Article em En | MEDLINE | ID: mdl-32880706
ABSTRACT
Attention-deficit hyperactivity disorder (ADHD) is associated with substantial personal and social impairments. Besides psychosocial interventions, current guidelines recommend a therapy with methylphenidate (MPH). This prospective, non-interventional study aims to investigate the efficacy and tolerability of MPH treatment of adult ADHD patients in a real-world setting. 468 adult patients with newly diagnosed ADHD were observed for 12-14 weeks. Primary efficacy endpoint was the clinical global impression (CGI) by the physician. Secondary endpoints comprise patient evaluation (Wender-Reimherr self-report, WR-SR), safety, tolerability, and dosage of MPH. With a mean daily dose of 35.8 (±17.0) mg MPH, the population of patients being severely/most extremely ill or markedly ill decreased by 64% and 61%, respectively. According to physicians' assessment (CGI), 74.5% of patients were identified as treatment responders. The total score of patient-based assessment (WR-SR) improved by 23.5% (50.1 ± 40.3 points) with the most profound improvement in attention deficit (-30.0%), disorganization (-26.6%), and hyperactivity / unrest (-23.3%). Self-evaluation revealed a responder rate of 35.4%. In summary, MPH treatment improves the degree of ADHD severity under routine conditions. In addition, activities of daily living were facilitated when taking MPH. The rather poor responder rates determined by patient assessment as well as the comparatively low applied mean daily dose of 35.8 mg (median 40 mg) indicate sub-optimal dosing under routine conditions, not exploiting the full beneficial therapeutic potential of MPH.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Estimulantes do Sistema Nervoso Central / Metilfenidato Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Estimulantes do Sistema Nervoso Central / Metilfenidato Idioma: En Ano de publicação: 2020 Tipo de documento: Article