Origanum vulgare L.: In vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells.

Mir, Reyaz H; Sawhney, Gifty; Verma, Rohini; Ahmad, Bilal; Kumar, Parveen; Ranjana, Soni; Bhagat, Asha; Madishetti, Sreedhar; Ahmed, Zabeer; Jachak, Sanjay M; Choi, Sangdun; Masoodi, Mubashir H

Mir, Reyaz H; Sawhney, Gifty; Verma, Rohini; Ahmad, Bilal; Kumar, Parveen; Ranjana, Soni; Bhagat, Asha; Madishetti, Sreedhar; Ahmed, Zabeer; Jachak, Sanjay M; Choi, Sangdun; Masoodi, Mubashir H.

Afiliação

Mir RH; Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Kashmir, India.
Sawhney G; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu 180001, India.
Verma R; Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali 160062, Punjab, India.
Ahmad B; Department of Molecular Science and Technology, Ajou University, South Korea.
Kumar P; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu 180001, India.
Ranjana S; Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali 160062, Punjab, India.
Bhagat A; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu 180001, India.
Madishetti S; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu 180001, India.
Ahmed Z; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu 180001, India.
Jachak SM; Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali 160062, Punjab, India.
Choi S; Department of Molecular Science and Technology, Ajou University, South Korea.
Masoodi MH; Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Kashmir, India.

Med Chem ; 17(9): 983-993, 2021.

Article em En | MEDLINE | ID: mdl-32885758

Assuntos

Anti-Inflamatórios/farmacologia; Antioxidantes/farmacologia; Origanum/química; Animais; Anti-Inflamatórios/química; Antioxidantes/química; Sobrevivência Celular/efeitos dos fármacos; Cinamatos/química; Cinamatos/metabolismo; Citocinas/metabolismo; Depsídeos/química; Depsídeos/metabolismo; Dexametasona/química; Dexametasona/metabolismo; Avaliação Pré-Clínica de Medicamentos; Interleucina-1beta/química; Interleucina-1beta/metabolismo; Lipopolissacarídeos/farmacologia; Camundongos; Simulação de Acoplamento Molecular; Óxido Nítrico/metabolismo; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Folhas de Planta/química; Células RAW 264.7; Fator de Necrose Tumoral alfa/química; Fator de Necrose Tumoral alfa/metabolismo; Ácido Rosmarínico

Palavras-chave

IL-6; LPS; Phytoconstituents; anti-inflammatory.; inflammation; traditional medicine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Origanum / Anti-Inflamatórios / Antioxidantes Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Origanum / Anti-Inflamatórios / Antioxidantes Idioma: En Ano de publicação: 2021 Tipo de documento: Article