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Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.
Macharia, Gladys N; Yue, Ling; Staller, Ecco; Dilernia, Dario; Wilkins, Daniel; Song, Heeyah; McGowan, Edward; King, Deborah; Fast, Pat; Imami, Nesrina; Price, Matthew A; Sanders, Eduard J; Hunter, Eric; Gilmour, Jill.
Afiliação
  • Macharia GN; Department of Medicine, Imperial College London, London, United Kingdom.
  • Yue L; IAVI Human Immunology Laboratory, London, United Kingdom.
  • Staller E; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
  • Dilernia D; Department of Medicine, Imperial College London, London, United Kingdom.
  • Wilkins D; IAVI Human Immunology Laboratory, London, United Kingdom.
  • Song H; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
  • McGowan E; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
  • King D; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
  • Fast P; Department of Medicine, Imperial College London, London, United Kingdom.
  • Imami N; IAVI Human Immunology Laboratory, London, United Kingdom.
  • Price MA; Department of Medicine, Imperial College London, London, United Kingdom.
  • Sanders EJ; IAVI Human Immunology Laboratory, London, United Kingdom.
  • Hunter E; IAVI, New York, NY, United States of America.
  • Gilmour J; Department of Medicine, Imperial College London, London, United Kingdom.
PLoS Pathog ; 16(9): e1008853, 2020 09.
Article em En | MEDLINE | ID: mdl-32886726
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Efeito Fundador / Produtos do Gene gag do Vírus da Imunodeficiência Humana Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Efeito Fundador / Produtos do Gene gag do Vírus da Imunodeficiência Humana Idioma: En Ano de publicação: 2020 Tipo de documento: Article