Role of bacterial infections in extracellular vesicles release and impact on immune response.
Biomed J
; 44(2): 157-164, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-32888911
Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infection and cell type, EV cargo composition changes and ultimately might impact the host immune response and bacterial growth. The mechanisms behind the EVs release, cargo composition, and impact on the immune system have not been fully investigated. Future research needs to include in vivo models to understand the relevance of EVs in host immune function during bacterial infection, and to determine aspects that are shared or species-specific in the host. This would aid in the development of EVs as therapeutics or as markers of disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
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Exossomos
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Vesículas Extracelulares
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article