Responsive neurostimulation for refractory epilepsy in the pediatric population: A single-center experience.
Epilepsy Behav
; 112: 107389, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32890796
ABSTRACT
Drug-resistant focal epilepsy (DRFE) in children can impair cognition and behavior, and lead to premature death. Increased pediatric epilepsy surgery numbers reflect the improvements in seizure control and long-term developmental outcomes. Yet, many children with DRFE are not candidates for surgical resection due to overlap of the seizure network with eloquent cortex or multiple seizure-onset zones, making surgery dangerous or ineffective. In adults, responsive neurostimulation (RNS System) therapy is safe and effective treatment for DRFE with one or two seizure foci, especially when the seizure focus is in eloquent cortex. We present six pediatric patients with DRFE who underwent RNS implantation. Our outcomes demonstrate safety, decreased clinical seizure frequency, as well as improved functional status and quality of life. Changes in the clinical seizure semiology and frequency occurred in conjunction with adjustments to the stimulation parameters, supporting the efficacy of responsive neuromodulation in children.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estimulação Encefálica Profunda
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Epilepsia
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Epilepsia Resistente a Medicamentos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article