Effects of Body Weight on Bleeding and Ischemic Events in Patients Undergoing Percutaneous Coronary Interventionã- From the CREDO-Kyoto Registry Cohort-2.
Circ J
; 84(10): 1734-1745, 2020 09 25.
Article
em En
| MEDLINE
| ID: mdl-32893236
ABSTRACT
BACKGROUND:
The effect of body weight (BW) on bleeding and ischemic events has not been adequately evaluated in real-world percutaneous coronary intervention (PCI) practice.MethodsâandâResults:
12,690 consecutive patients undergoing first PCI in the CREDO-Kyoto registry cohort-2 were divided into 3 groups according to tertiles of BW stratified by sex (male; Tertile 1 [<60.0 kg], 2 [60.0-68.0 kg], and 3 [>68.0 kg], and female; Tertile 1 [<47.9 kg], 2 [47.9-55.8 kg], and 3 [>55.8 kg]). Cumulative 5-year incidences of the primary bleeding (GUSTO moderate/severe) and ischemic (myocardial infarction/ischemic stroke) endpoints increased incrementally with decrease in BW in both strata (male Tertiles 1, 2, and 3 13.7%, 10.3%, and 8.0%, P<0.001, and 13.9%, 11.3%, and 10.2%, P<0.001; female Tertiles 1, 2, and 3 17.9%, 12.9%, and 10.1%, P<0.001, and 17.9%, 12.9%, and 10.1%, P<0.001). Compared with Tertile 3, the adjusted risks of Tertile 1 for the primary bleeding and ischemic endpoints remained significant in the female stratum (hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.14-1.87, P=0.003, and HR1.49, 95% CI1.13-1.95, P=0.004), but not in the male stratum (HR1.10, 95% CI0.92-1.32, P=0.31, and HR1.06, 95% CI0.90-1.27, P=0.47).CONCLUSIONS:
Cumulative incidences of bleeding and ischemic events increased incrementally as BW decreased in both men and women. The adjusted risks of underweight relative to overweight for bleeding and ischemic events were significant only in women.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
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Doença da Artéria Coronariana
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Sistema de Registros
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Intervenção Coronária Percutânea
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AVC Isquêmico
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Hemorragia
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Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article