Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers.
Nutrients
; 12(9)2020 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-32899873
ABSTRACT
The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ± 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ± 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ± 80.37, 2757.79 ± 1926.11, and 1044.76 ± 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Órgãos
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Ciclosporina
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Colostro
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Imunossupressores
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article