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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
Futatsugi, Kentaro; Smith, Aaron C; Tu, Meihua; Raymer, Brian; Ahn, Kay; Coffey, Steven B; Dowling, Matthew S; Fernando, Dilinie P; Gutierrez, Jemy A; Huard, Kim; Jasti, Jayasankar; Kalgutkar, Amit S; Knafels, John D; Pandit, Jayvardhan; Parris, Kevin D; Perez, Sylvie; Pfefferkorn, Jeffrey A; Price, David A; Ryder, Tim; Shavnya, Andre; Stock, Ingrid A; Tsai, Andy S; Tesz, Gregory J; Thuma, Benjamin A; Weng, Yan; Wisniewska, Hanna M; Xing, Gang; Zhou, Jun; Magee, Thomas V.
Afiliação
  • Futatsugi K; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Smith AC; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Tu M; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Raymer B; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Ahn K; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Coffey SB; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Dowling MS; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Fernando DP; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Gutierrez JA; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Huard K; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Jasti J; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Kalgutkar AS; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Knafels JD; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Pandit J; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Parris KD; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Perez S; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Pfefferkorn JA; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Price DA; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Ryder T; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Shavnya A; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Stock IA; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Tsai AS; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Tesz GJ; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Thuma BA; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Weng Y; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Wisniewska HM; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Xing G; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Zhou J; Pfizer Inc. Drug Safety R&D, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Magee TV; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 63(22): 13546-13560, 2020 11 25.
Article em En | MEDLINE | ID: mdl-32910646
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Descoberta de Drogas / Frutoquinases / Frutose / Doenças Metabólicas Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Descoberta de Drogas / Frutoquinases / Frutose / Doenças Metabólicas Idioma: En Ano de publicação: 2020 Tipo de documento: Article