Integrative, genome-wide association study identifies chemicals associated with common women's malignancies.
Genomics
; 112(6): 5029-5036, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32911025
ABSTRACT
BACKGROUND:
Breast cancer, cervical cancer, and ovarian cancer are three of the most commonly diagnosed malignancies in women, and more cancer prevention research is urgently needed.METHODS:
Summary data of a large genome-wide association study of female cancers were derived from the UK biobank. We performed a transcriptome-wide association study and a gene set enrichment analysis to identify correlations between chemical exposure and aberrant expression, repression, or mutation of genes related to cancer using the Comparative Toxicogenomics Database.RESULTS:
We identified five chemicals (NSC668394, glafenine, methylnitronitrosoguanidine, fenofibrate, and methylparaben) that were associated with the incidence of both breast cancer and cervical cancer.CONCLUSION:
Using a transcriptome-wide association study and gene set enrichment analysis we identified environmental chemicals that are associated with an increased risk of breast cancer, cervical cancer, and ovarian cancer.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Neoplasias da Mama
/
Neoplasias do Colo do Útero
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article