Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module.
Biochim Biophys Acta Gene Regul Mech
; 1864(2): 194630, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-32911111
ABSTRACT
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex is a critical regulator of gene expression and is highly conserved across species. Subunits of SAGA arrange into discrete modules with lysine aceyltransferase and deubiquitinase activities housed separately. Mutation of the SAGA deubiquitinase module can lead to substantial biological misfunction and diseases such as cancer, neurodegeneration, and blindness. Here, we review the structure and functions of the SAGA deubiquitinase module and regulatory mechanisms acting to control these.
Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ativação Transcricional
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Transativadores
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Fatores de Transcrição de p300-CBP
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Enzimas Desubiquitinantes
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Complexos Multienzimáticos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article