Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors.

Meden, Anze; Knez, Damijan; Malikowska-Racia, Natalia; Brazzolotto, Xavier; Nachon, Florian; Svete, Jurij; Salat, Kinga; Groselj, Uros; Gobec, Stanislav

Meden, Anze; Knez, Damijan; Malikowska-Racia, Natalia; Brazzolotto, Xavier; Nachon, Florian; Svete, Jurij; Salat, Kinga; Groselj, Uros; Gobec, Stanislav.

Afiliação

Meden A; University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI-1000, Ljubljana, Slovenia.
Knez D; University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI-1000, Ljubljana, Slovenia.
Malikowska-Racia N; Department of Pharmacodynamics, Chair of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688, Krakow, Poland.
Brazzolotto X; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91223, Brétigny sur Orge, France.
Nachon F; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91223, Brétigny sur Orge, France.
Svete J; University of Ljubljana, Faculty of Chemistry and Chemical Technology, Vecna Pot 113, SI-1000, Ljubljana, Slovenia.
Salat K; Department of Pharmacodynamics, Chair of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688, Krakow, Poland.
Groselj U; University of Ljubljana, Faculty of Chemistry and Chemical Technology, Vecna Pot 113, SI-1000, Ljubljana, Slovenia. Electronic address: uros.groselj@fkkt.uni-lj.si.
Gobec S; University of Ljubljana, Faculty of Pharmacy, Askerceva 7, SI-1000, Ljubljana, Slovenia. Electronic address: stanislav.gobec@ffa.uni-lj.si.

Eur J Med Chem ; 208: 112766, 2020 Dec 15.

Article em En | MEDLINE | ID: mdl-32919297

Assuntos

Doença de Alzheimer/tratamento farmacológico; Butirilcolinesterase/metabolismo; Inibidores da Colinesterase/uso terapêutico; Nootrópicos/uso terapêutico; Triptofano/análogos & derivados; Triptofano/uso terapêutico; Animais; Inibidores da Colinesterase/síntese química; Inibidores da Colinesterase/toxicidade; Aprendizagem em Labirinto/efeitos dos fármacos; Memória/efeitos dos fármacos; Camundongos; Estrutura Molecular; Nootrópicos/síntese química; Nootrópicos/toxicidade; Relação Estrutura-Atividade; Triptofano/toxicidade

Palavras-chave

Alzheimer's disease; Butyrylcholinesterase; Cholinesterase inhibitors; Neurodegenerative diseases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano / Butirilcolinesterase / Inibidores da Colinesterase / Nootrópicos / Doença de Alzheimer Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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