Inteurleukin-8 gene variations and the susceptibility to schizophrenia.
Psychiatry Res
; 293: 113421, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32920525
ABSTRACT
The relevance of Interleukin-8 (IL-8) cytokine alteration in the peripheral and central system has been widely shown in psychosis while variation in the IL-8 gene remains largely unexplored and to the best of our knowledge, IL-8 polymorphisms have never been specifically targeted in Schizophrenia (Scz). Thus, we set out to search a potential correlation between rs4073, rs2227306 and rs1126647 polymorphisms in IL-8 gene and the development of Scz in a sample of the Tunisian population in a candidate gene approach. Targeted polymorphisms were analysed in 206 patients and 195 controls using PCR-RFLP method. Among all analysed polymorphisms, only rs1126647 showed a significant risk for Scz. After stratification analysis, we noted a significant association of TT genotype and T allele at rs1126647 with paranoid form, and more specifically with female sex. We find that the rare haplotypes at rs4073-rs2227306-rs1126647 of TTT, ACT and TCT, each containing the risk allele rs1126647T, were associated with increased risk for paranoid Scz while only the TCT combination constituted a risk factor for Scz more generally. Our findings support that IL-8 gene may be involved in susceptibility to Scz but this still preliminary and needs to be strengthened by further independent analyses.
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MEDLINE
Assunto principal:
Esquizofrenia
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Variação Genética
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Interleucina-8
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article