Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC.

Kong, Liang; Zhang, Shi-Meng; Chu, Jia-Hao; Liu, Xin-Ze; Zhang, Lu; He, Si-Yu; Yang, Si-Min; Ju, Rui-Jun; Li, Xue-Tao

Kong, Liang; Zhang, Shi-Meng; Chu, Jia-Hao; Liu, Xin-Ze; Zhang, Lu; He, Si-Yu; Yang, Si-Min; Ju, Rui-Jun; Li, Xue-Tao.

Afiliação

Kong L; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Zhang SM; Department of Neurology, Linyi People's Hospital, Linyi 276003, People's Republic of China.
Chu JH; Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People's Republic of China.
Liu XZ; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Zhang L; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
He SY; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Yang SM; Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People's Republic of China.
Ju RJ; Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People's Republic of China.
Li XT; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.

Int J Nanomedicine ; 15: 6451-6468, 2020.

Article em En | MEDLINE | ID: mdl-32922011

Assuntos

Antineoplásicos/uso terapêutico; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Neoplasias Pulmonares/tratamento farmacológico; Microambiente Tumoral; Células A549; Animais; Antineoplásicos/farmacologia; Carcinoma Pulmonar de Células não Pequenas/patologia; Morte Celular/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Galinhas; Endocitose/efeitos dos fármacos; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Humanos; Hidrólise; Lipossomos; Neoplasias Pulmonares/patologia; Camundongos Endogâmicos BALB C; Camundongos Nus; Invasividade Neoplásica; Neovascularização Patológica/tratamento farmacológico; Neovascularização Patológica/patologia; Fosfatidiletanolaminas/química; Polietilenoglicóis/química; Microambiente Tumoral/efeitos dos fármacos; Vinorelbina/farmacologia; Vinorelbina/uso terapêutico

Palavras-chave

MMP2 enzymes; dioscin; multi-functional liposomes; non-small cell lung cancer; tumor microenvironment; vinorelbine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Microambiente Tumoral / Neoplasias Pulmonares / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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