A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied.

Ye, Jing-Yi; Chen, Zhong-Yun; Huang, Chuan-Li; Huang, Bei; Zheng, Yu-Rong; Zhang, Ying-Feng; Lu, Ban-Yi; He, Lin; Liu, Chang-Shun; Long, Xiao-Ying

Ye, Jing-Yi; Chen, Zhong-Yun; Huang, Chuan-Li; Huang, Bei; Zheng, Yu-Rong; Zhang, Ying-Feng; Lu, Ban-Yi; He, Lin; Liu, Chang-Shun; Long, Xiao-Ying.

Afiliação

Ye JY; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Chen ZY; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Huang CL; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Huang B; School of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Zheng YR; School of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Zhang YF; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Lu BY; School of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
He L; School of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Liu CS; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Long XY; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.

Int J Nanomedicine ; 15: 6503-6518, 2020.

Article em En | MEDLINE | ID: mdl-32922013

Assuntos

Absorção Fisico-Química; Emulsões/química; Lipólise; Nanopartículas/química; Cloridrato de Raloxifeno/metabolismo; Administração Oral; Animais; Disponibilidade Biológica; Transporte Biológico; Sobrevivência Celular; Cães; Emulsões/administração & dosagem; Feminino; Intestinos/fisiologia; Linfa/metabolismo; Células Madin Darby de Rim Canino; Masculino; Polietilenoglicóis; Ratos Sprague-Dawley; Tensoativos/química; Suínos

Palavras-chave

bioavailability; endocytosis; first-pass metabolism; non-lipolysis nanoemulsion; raloxifene; stability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cloridrato de Raloxifeno / Emulsões / Nanopartículas / Absorção Fisico-Química / Lipólise Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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