Mechanisms Underlying the Regulation of Mitochondrial Respiratory Chain Complexes by Nuclear Steroid Receptors.
Int J Mol Sci
; 21(18)2020 Sep 12.
Article
em En
| MEDLINE
| ID: mdl-32932692
ABSTRACT
Mitochondrial respiratory chain complexes play important roles in energy production via oxidative phosphorylation (OXPHOS) to drive various biochemical processes in eukaryotic cells. These processes require coordination with other cell organelles, especially the nucleus. Factors encoded by both nuclear and mitochondrial DNA are involved in the formation of active respiratory chain complexes and 'supercomplexes', the higher-order structures comprising several respiratory chain complexes. Various nuclear hormone receptors are involved in the regulation of OXPHOS-related genes. In this article, we review the roles of nuclear steroid receptors (NR3 class nuclear receptors), including estrogen receptors (ERs), estrogen-related receptors (ERRs), glucocorticoid receptors (GRs), mineralocorticoid receptors (MRs), progesterone receptors (PRs), and androgen receptors (ARs), in the regulatory mechanisms of mitochondrial respiratory chain complex and supercomplex formation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Esteroides
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Núcleo Celular
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Transporte de Elétrons
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Mitocôndrias
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article