Mitochondrial Dysfunction in Obesity and Reproduction.
Endocrinology
; 162(1)2021 01 01.
Article
em En
| MEDLINE
| ID: mdl-32945868
ABSTRACT
Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central role of mitochondria in energy production, heme biosynthesis, calcium buffering, steroidogenesis, and apoptosis signaling within cells, understanding the molecular mechanisms behind mitochondrial dysregulation and its potential implications in disease is critical. This review will take a journey through the past and summarize what is known about mitochondrial dysfunction in various disorders, focusing on metabolic alterations and reproductive abnormalities. Evidence is presented from studies in different human populations, and rodents with genetic manipulations of pathways known to affect mitochondrial function.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Mitocondriais
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Infertilidade
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Obesidade
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article