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Lipid levels, atrial fibrillation and the impact of age: Results from the LIPIDOGRAM2015 study.
Harrison, Stephanie L; Lane, Deirdre A; Banach, Maciej; Mastej, Miroslaw; Kasperczyk, Slawomir; Józwiak, Jacek J; Lip, Gregory Y H.
Afiliação
  • Harrison SL; Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital & University of Liverpool, Liverpool, United Kingdom. Electronic address: stephanie.harrison@liverpool.ac.uk.
  • Lane DA; Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital & University of Liverpool, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Banach M; Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113, 90-549, Lodz, Poland.
  • Mastej M; Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Oleska 48, 45-052, Opole, Poland.
  • Kasperczyk S; Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Jordana 19 41-808 Zabrze, Medical University of Silesia, Katowice, Poland.
  • Józwiak JJ; Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Oleska 48, 45-052, Opole, Poland. Electronic address: jacek.jozwiak@uni.opole.pl.
  • Lip GYH; Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital & University of Liverpool, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Atherosclerosis ; 312: 16-22, 2020 11.
Article em En | MEDLINE | ID: mdl-32947222
BACKGROUND AND AIMS: An inverse relationship between lipid levels and atrial fibrillation (AF) has been suggested, but whether the association is upheld for all age groups remains unclear. The aim of the study was to examine associations between lipid levels and AF by age groups in a nationwide study in Poland. METHODS: Multivariate Poisson regression models were used to estimate prevalence ratios (PRs) for AF by lipid levels. Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), non-HDL-C and LDL-C/HDL-C ratios were grouped into quartiles. RESULTS: Of the 13,724 participants, 5.2% (n = 708) had AF. People with AF were older with more comorbidities, but lower lipid levels (all p < 0.05). The prevalence of AF was inversely associated with LDL-C (Adjusted PR (95% Confidence Interval) highest versus lowest quartile: 0.60 (0.48, 0.75)), TC (0.61 (0.49, 0.75)) and non-HDL-C (0.63 (0.51, 0.78)). The prevalence of AF was inversely associated with HDL-C (0.58 (0.46, 0.74)), but this was not statistically significant for people aged 75 years and older. For the LDL-C/HDL-C ratio, the prevalence of AF was only inversely associated with higher levels for people aged 75 years and older (0.75 (0.61, 0.94)). There was no statistically significant difference in prevalence of AF by TG levels. CONCLUSIONS: The results suggest an inverse relationship between lipid levels and AF. The inverse association between higher HDL-C and AF was only significant for people aged <75 years, whereas the inverse association between higher LDL-C/HDL-C ratio and AF was only significant for people aged 75 years and older.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial Idioma: En Ano de publicação: 2020 Tipo de documento: Article