Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.

Johnson, Michelle A; Deng, Qiudong; Taylor, Georgia; McEachin, Zachary T; Chan, Anthony W S; Root, Jessica; Bassell, Gary J; Kukar, Thomas

Johnson, Michelle A; Deng, Qiudong; Taylor, Georgia; McEachin, Zachary T; Chan, Anthony W S; Root, Jessica; Bassell, Gary J; Kukar, Thomas.

Afiliação

Johnson MA; Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America.
Deng Q; Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America.
Taylor G; Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America.
McEachin ZT; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Cell Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Laboratory of Translational Cell Biology, Emory University, School of Medicine,
Chan AWS; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Human Genetics, Emory University, School of Medicine, Atlanta, GA, United States of America; Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate
Root J; Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America.
Bassell GJ; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Cell Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Laboratory of Translational Cell Biology, Emory University, School of Medicine,
Kukar T; Department of Pharmacology and Chemical Biology, Emory University, School of Medicine, Atlanta, GA, United States of America; Center for Neurodegenerative Disease, Emory University, School of Medicine, Atlanta, GA, United States of America; Department of Neurology, Emory University, School of Medici

Neurobiol Dis ; 146: 105085, 2020 12.

Article em En | MEDLINE | ID: mdl-32950644

Assuntos

Encéfalo/metabolismo; Dano ao DNA/fisiologia; DNA/metabolismo; Degeneração Lobar Frontotemporal/metabolismo; Proteína FUS de Ligação a RNA/genética; Animais; Degeneração Lobar Frontotemporal/genética; Humanos; Corpos de Inclusão/genética; Corpos de Inclusão/metabolismo; Camundongos; Mutação/genética; Neurônios/metabolismo; Fosforilação; Fatores Associados à Proteína de Ligação a TATA/genética

Palavras-chave

Amyotrophic lateral sclerosis (ALS); Calicheamicin Î³1 (CLM); DNA damage; DNA-dependent protein kinase (DNA-PK); Frontotemporal dementia (FTD); Fused in sarcoma (FUS); Phosphorylation; Species specific response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Encéfalo / DNA / Proteína FUS de Ligação a RNA / Degeneração Lobar Frontotemporal Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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