Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits.
Adv Protein Chem Struct Biol
; 122: 231-288, 2020.
Article
em En
| MEDLINE
| ID: mdl-32951813
ABSTRACT
Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts with a large variety of proteins of diverse structure (regulatory subunits). The diversity of holoenzymes that can be formed explain the multiplicity of cellular functions under the control of this phosphatase. In quite a few cases, regulatory subunits have an inhibitory role, downregulating the activity of the phosphatase. In this chapter we shall introduce PP1C and review the most relevant families of PP1C regulatory subunits, with particular emphasis in describing the structural basis for their interaction.
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MEDLINE
Assunto principal:
Proteína Fosfatase 1
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article