Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation.
Bioorg Chem
; 104: 104258, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32956876
ABSTRACT
Five new nitrogen-containing compounds (1-3, 5, and 6), two compounds which was firstly isolated from natural origin (7 and 10), along with six known ones, were isolated from the ethanol extract of the whole bodies of Polyphaga plancyi. The structures of the new compounds including their absolute configurations at stereogenic centers were assigned on the basis of spectroscopic analyses and computational methods. Racemic 10 was separated by chiral HPLC. Biological activities of these isolates against extracellular matrix components in rat renal proximal tubular cells, EV71, COX-2, ROCK2, JAK3, and tuberculosis were evaluated. Importantly, 8 was found to be a selective Smad3 phosphorylation inhibitor.
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MEDLINE
Assunto principal:
Tuberculose
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Besouros
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Produtos Biológicos
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Inibidores Enzimáticos
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Ciclo-Oxigenase 2
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Janus Quinase 3
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Antituberculosos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article