Approaches to Understanding the Solution-State Organization of Spray-Dried Dispersion Feed Solutions and Its Translation to the Solid State.

Defrese, Matthew K; Farmer, Matthew A; Long, Yuhan; Timmerman, Lucas R; Bae, Younsoo; Marsac, Patrick J

Defrese, Matthew K; Farmer, Matthew A; Long, Yuhan; Timmerman, Lucas R; Bae, Younsoo; Marsac, Patrick J.

Afiliação

Defrese MK; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.
Farmer MA; Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Long Y; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky 40506, United States.
Timmerman LR; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky 40506, United States.
Bae Y; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.
Marsac PJ; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, United States.

Mol Pharm ; 17(12): 4548-4563, 2020 12 07.

Article em En | MEDLINE | ID: mdl-32965120

Assuntos

Composição de Medicamentos/métodos; Excipientes/química; Polímeros/química; Solventes/química; Disponibilidade Biológica; Química Farmacêutica; Dessecação; Estabilidade de Medicamentos; Transição de Fase; Solubilidade; Secagem por Atomização

Palavras-chave

intrinsic viscosity; light scattering; multicomponent solutions; preferential solvation; solvent quality; spray-dried amorphous dispersions

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Solventes / Composição de Medicamentos / Excipientes Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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