Heme biosynthesis in prokaryotes.
Biochim Biophys Acta Mol Cell Res
; 1868(1): 118861, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32976912
ABSTRACT
The cyclic tetrapyrrole heme is used as a prosthetic group in a broad variety of different proteins in almost all organisms. Often, it is essential for vital biochemical processes such as aerobic and anaerobic respiration as well as photosynthesis. In Nature, heme is made from the common tetrapyrrole precursor 5-aminolevulinic acid, and for a long time it was assumed that heme is biosynthesized by a single, common pathway in all organisms. However, although this is indeed the case in eukaryotes, heme biosynthesis is more diverse in the prokaryotic world, where two additional pathways exist. The final elucidation of the two 'alternative' heme biosynthesis routes operating in some bacteria and archaea was achieved within the last decade. This review summarizes the three different heme biosynthesis pathways with a special emphasis on the two 'new' prokaryotic routes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aerobiose
/
Tetrapirróis
/
Heme
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Anaerobiose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article