Capicua in Human Cancer.
Trends Cancer
; 7(1): 77-86, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32978089
ABSTRACT
Capicua (CIC) is a highly conserved transcriptional repressor that is differentially regulated through mitogen-activated protein kinase (MAPK) signaling or genetic alteration across human cancer. CIC contributes to tumor progression and metastasis through direct transcriptional control of effector target genes. Recent findings indicate that CIC dysregulation is mechanistically linked and restricted to specific cancer subtypes, yet convergence on key downstream transcriptional nodes are critical for CIC-regulated oncogenesis across these cancers. In this review, we focus on how differential regulation of CIC through functional and genetic mechanisms contributes to subtype-specific cancer phenotypes and we propose new therapeutic strategies to effectively target CIC-altered cancers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
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Regulação Neoplásica da Expressão Gênica
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Carcinogênese
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Neoplasias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article