The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis.
Crit Rev Oncol Hematol
; 155: 103075, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32987333
ABSTRACT
BACKGROUND:
This systematic review investigated the impact of complications on long term outcomes for patients with primary invasive operable breast cancer.METHODS:
A systematic review was performed using appropriate keywords, and meta-analysis using a random effects model completed.RESULTS:
Ten retrospective cohort studies, including 37,657 patients were included. Five studies identified a relationship between wound complications, infection and pyrexia and recurrence or recurrence-free survival. Risk of recurrence, 1-year and 5-year recurrence-free survival and overall survival were related to complications, particularly for patients with poor Nottingham Prognostic Index. Five studies failed to demonstrate a relationship between complications and prognosis. Complication was found to significantly affect 5-year recurrence-free survival (HR 1.48 95 % CI 1.02-2.14, p = 0.04) but not recurrence (HR 2.39, 95 %CI 0.94-6.07, p = 0.07), with a high degree of heterogeneity amongst analysed studies (I2 = 95 %).DISCUSSION:
Further research is needed to quantify the effects of postoperative complication on prognosis following surgery for breast cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article