Aerobic exercise has an anxiolytic effect on streptozotocininduced diabetic rats.
Acta Neurobiol Exp (Wars)
; 80(3): 245-255, 2020.
Article
em En
| MEDLINE
| ID: mdl-32990283
ABSTRACT
Diabetes is a metabolic disorder characterized by hyperglycemia and impaired insulin secretion or action. Psychological comorbidities, such as depression and anxiety, are more common in people with diabetes. Exercise results in anxiolytic effects, as demonstrated in numerous studies. This study aims to evaluate potential anxiolytic effects of aerobic exercise in streptozotocin (STZ)induced diabetes. Male Wistar albino rats (n=40) were randomly divided into four groups of control, exercise, diabetes, and diabetes + exercise. Diabetes was induced with a single i.p. injection of STZ. The incremental load test was applied to exercise groups to determine maximal exercise capacity. Rats exercised on a treadmill at 70% of their maximal capacity for 45 min, five days per week for 12 weeks. On the day after the last exercise session the open field test and elevated plus maze test were carried out. Diabetes caused an increase in anxiety level, reflected in stretchattend posture, selfgrooming behaviors, and freezing time, with no significant changes for other behavioral parameters. Training normalized diabetesinduced deteriorations and also induced a significant anxiolytic effect both on diabetic and nondiabetic rats. This effect was observed for all behavioral parameters. The results of the open field test and elevated plus maze were consistent. The current results demonstrated a slight increase in anxiety with diabetes and a prominent anxiolytic effect of aerobic exercise. Considering the conflicting results in exerciseanxiety studies, this study hig hlights the importance of individually designed exercise protocols.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Ansiolíticos
/
Comportamento Animal
/
Estreptozocina
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article