Improved Anti-Prion Nucleic Acid Aptamers by Incorporation of Chemical Modifications.
Nucleic Acid Ther
; 30(6): 414-421, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32991255
ABSTRACT
Nucleic acid aptamers are innovative and promising candidates to block the hallmark event in the prion diseases, that is the conversion of prion protein (PrP) into an abnormal form; however, they need chemical modifications for effective therapeutic activity. This communication reports on the development and biophysical characterization of a small library of chemically modified G-quadruplex-forming aptamers targeting the cellular PrP and the evaluation of their anti-prion activity. The results show the possibility of enhancing anti-prion aptamer properties through straightforward modifications.
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Base de dados:
MEDLINE
Assunto principal:
Príons
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Doenças Priônicas
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Aptâmeros de Nucleotídeos
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Técnica de Seleção de Aptâmeros
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article