Transformation to plasmablastic lymphoma in CLL upon ibrutinib treatment.
BMJ Case Rep
; 13(9)2020 Sep 29.
Article
em En
| MEDLINE
| ID: mdl-32994268
ABSTRACT
Chronic lymphatic leukaemia (CLL) is the most common leukaemia in the Western world. Ibrutinib, a tyrosine kinase inhibitor, is the treatment of choice on relapse or p53-dysfunction. Richter's transformation to diffuse large B cell lymphoma is most often seen. However, transformation to other aggressive lymphomas as plasmablastic lymphoma (PBL) does occur. PBL is an extremely aggressive lymphoma and is usually treated using a CHOP-like regimen (cyclophosphamide, doxorubicin, vincristine and prednisone/dexamethasone), but with poor outcome. The only curative treatment is allogeneic stem cell transplant (ASCT).We report on a case of CLL treated with ibrutinib that underwent transformation to PBL. Due to high expression of CD138, we added daratumumab to the chemotherapy with a good, but transitory response. The case did not make it to an ASCT. Targeting CD138 by daratumumab may be added to chemoimmune therapy for PBL.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Adenina
/
Leucemia Linfocítica Crônica de Células B
/
Transformação Celular Neoplásica
/
Linfoma Plasmablástico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article