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Vaccines against components of the renin-angiotensin system.
Garay-Gutiérrez, Noé Francisco; Hernandez-Fuentes, Carolina Paz; García-Rivas, Gerardo; Lavandero, Sergio; Guerrero-Beltrán, Carlos Enrique.
Afiliação
  • Garay-Gutiérrez NF; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabolómica, Tecnologico de Monterrey, Monterrey, NL, Mexico.
  • Hernandez-Fuentes CP; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
  • García-Rivas G; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabolómica, Tecnologico de Monterrey, Monterrey, NL, Mexico.
  • Lavandero S; Hospital Zambrano Hellion, TecSalud, Centro de Investigación Biomédica, Tecnologico de Monterrey, San Pedro Garza García, NL, Mexico.
  • Guerrero-Beltrán CE; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas y Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Heart Fail Rev ; 26(3): 711-726, 2021 05.
Article em En | MEDLINE | ID: mdl-32995973
Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important factors that contribute to the global problem of uncontrolled hypertension. Vaccination could provide a revolutionary therapy with long-lasting effects, increasing patient compliance and therefore better control of high blood pressure. Nowadays, current immunization approaches against hypertension target renin, angiotensin I, angiotensin II, and angiotensin II type 1 receptor, key elements of the renin-angiotensin system. This article reviews the different vaccination attempts with proteins and peptides against the different molecules of the renin-angiotensin system in the last two decades, safety issues, and other novel prospects biomarkers in hypertension, and summarizes the potential of this immunomodulatory approach in clinical practice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas / Hipertensão Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas / Hipertensão Idioma: En Ano de publicação: 2021 Tipo de documento: Article