Decoding the Papain Inhibitor from <i>Streptomyces mobaraensis</i> as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway.

Juettner, Norbert E; Bogen, Jan P; Bauer, Tobias A; Knapp, Stefan; Pfeifer, Felicitas; Huettenhain, Stefan H; Meusinger, Reinhard; Kraemer, Andreas; Fuchsbauer, Hans-Lothar

Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway.

Juettner, Norbert E; Bogen, Jan P; Bauer, Tobias A; Knapp, Stefan; Pfeifer, Felicitas; Huettenhain, Stefan H; Meusinger, Reinhard; Kraemer, Andreas; Fuchsbauer, Hans-Lothar.

Afiliação

Juettner NE; The Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Stephanstraße 7, 64295 Darmstadt, Germany.
Bogen JP; The Department of Biology, Technische Universität Darmstadt, Schnittspahnstraße 10, 64287 Darmstadt, Germany.
Bauer TA; The Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Stephanstraße 7, 64295 Darmstadt, Germany.
Knapp S; The Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Stephanstraße 7, 64295 Darmstadt, Germany.
Pfeifer F; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.
Huettenhain SH; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences (BMLS), Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany.
Meusinger R; The Department of Biology, Technische Universität Darmstadt, Schnittspahnstraße 10, 64287 Darmstadt, Germany.
Kraemer A; The Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Stephanstraße 7, 64295 Darmstadt, Germany.
Fuchsbauer HL; The Department of Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Straße 8, 64287 Darmstadt, Germany.

J Nat Prod ; 83(10): 2983-2995, 2020 10 23.

Article em En | MEDLINE | ID: mdl-32998509

Assuntos

Inibidores Enzimáticos/farmacologia; Oligopeptídeos; Papaína/antagonistas & inibidores; Streptomyces; Aldeídos; Sequência de Aminoácidos; Vias Biossintéticas; Hidroxilação; Modelos Moleculares; Estrutura Molecular; Peptídeo Sintases; Especificidade por Substrato

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Streptomyces / Papaína / Inibidores Enzimáticos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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