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Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques.
Peli, Simone; Ronchi, Andrea; Bianchetti, Giada; Rossella, Francesco; Giannetti, Claudio; Chiari, Marcella; Pingue, Pasqualantonio; Banfi, Francesco; Ferrini, Gabriele.
Afiliação
  • Peli S; Interdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
  • Ronchi A; Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
  • Bianchetti G; Interdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
  • Rossella F; Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
  • Giannetti C; Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, 3001, Leuven, Belgium.
  • Chiari M; Interdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
  • Pingue P; Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, 25121, Brescia, Italy.
  • Banfi F; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.
  • Ferrini G; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Sci Rep ; 10(1): 16230, 2020 10 01.
Article em En | MEDLINE | ID: mdl-33004805
The thermo-mechanical properties of streptavidin-conjugated gold nanospheres, adhered to a surface via complex molecular chains, are investigated by two-color infrared asynchronous optical sampling pump-probe spectroscopy. Nanospheres with different surface densities have been deposited and exposed to a plasma treatment to modify their polymer binding chains. The aim is to monitor their optical response in complex chemical environments that may be experienced in, e.g., photothermal therapy or drug delivery applications. By applying unsupervised learning techniques to the spectroscopic traces, we identify their thermo-mechanical response variation. This variation discriminates nanospheres in different chemical environments or different surface densities. Such discrimination is not evident based on a standard analysis of the spectroscopic traces. This kind of analysis is important, given the widespread application of conjugated gold nanospheres in medicine and biology.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article