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A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.
Balderston, Nicholas L; Roberts, Camille; Beydler, Emily M; Deng, Zhi-De; Radman, Thomas; Luber, Bruce; Lisanby, Sarah H; Ernst, Monique; Grillon, Christian.
Afiliação
  • Balderston NL; Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. nicholas.balderston@pennmedicine.upenn.edu.
  • Roberts C; Center for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. nicholas.balderston@pennmedicine.upenn.edu.
  • Beydler EM; Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Deng ZD; Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Radman T; Noninvasive Neuromodulation Unit, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Luber B; Noninvasive Neuromodulation Unit, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Lisanby SH; Noninvasive Neuromodulation Unit, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Ernst M; Noninvasive Neuromodulation Unit, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Grillon C; Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Nat Protoc ; 15(11): 3595-3614, 2020 11.
Article em En | MEDLINE | ID: mdl-33005039
Transcranial magnetic stimulation (TMS) is a noninvasive method to stimulate the cerebral cortex that has applications in psychiatry, such as in the treatment of depression and anxiety. Although many TMS targeting methods that use figure-8 coils exist, many do not account for individual differences in anatomy or are not generalizable across target sites. This protocol combines functional magnetic resonance imaging (fMRI) and iterative electric-field (E-field) modeling in a generalized approach to subject-specific TMS targeting that is capable of optimizing the stimulation site and TMS coil orientation. To apply this protocol, the user should (i) operationally define a region of interest (ROI), (ii) generate the head model from the structural MRI data, (iii) preprocess the functional MRI data, (iv) identify the single-subject stimulation site within the ROI, and (iv) conduct E-field modeling to identify the optimal coil orientation. In comparison with standard targeting methods, this approach demonstrates (i) reduced variability in the stimulation site across subjects, (ii) reduced scalp-to-cortical-target distance, and (iii) reduced variability in optimal coil orientation. Execution of this protocol requires intermediate-level skills in structural and functional MRI processing. This protocol takes ~24 h to complete and demonstrates how constrained fMRI targeting combined with iterative E-field modeling can be used as a general method to optimize both the TMS coil site and its orientation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética / Estimulação Magnética Transcraniana Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética / Estimulação Magnética Transcraniana Idioma: En Ano de publicação: 2020 Tipo de documento: Article