Small molecule induced toxic human-IAPP species characterized by NMR.
Chem Commun (Camb)
; 56(86): 13129-13132, 2020 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-33006345
ABSTRACT
In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-ß1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobre
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Curcumina
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Bibliotecas de Moléculas Pequenas
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Polipeptídeo Amiloide das Ilhotas Pancreáticas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article