Interactions of galeterone and its 3-keto-&#916;4 metabolite (D4G) with one of the key enzymes of corticosteroid biosynthesis - steroid 21-monooxygenase (CYP21A2).

Masamrekh, Rami A; Filippova, Tatiana A; Sherbakov, Kirill A; Veselovsky, Alexander V; Shumyantseva, Victoria V; Kuzikov, Alexey V

Interactions of galeterone and its 3-keto-Δ4 metabolite (D4G) with one of the key enzymes of corticosteroid biosynthesis - steroid 21-monooxygenase (CYP21A2).

Masamrekh, Rami A; Filippova, Tatiana A; Sherbakov, Kirill A; Veselovsky, Alexander V; Shumyantseva, Victoria V; Kuzikov, Alexey V.

Afiliação

Masamrekh RA; Pirogov Russian National Research Medical University, Ostrovitianov Street, 1, Moscow, 117997, Russia.
Filippova TA; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, Moscow, 119121, Russia.
Sherbakov KA; Pirogov Russian National Research Medical University, Ostrovitianov Street, 1, Moscow, 117997, Russia.
Veselovsky AV; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, Moscow, 119121, Russia.
Shumyantseva VV; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, Moscow, 119121, Russia.
Kuzikov AV; Institute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, Moscow, 119121, Russia.

Fundam Clin Pharmacol ; 35(2): 423-431, 2021 Apr.

Article em En | MEDLINE | ID: mdl-33012006

Assuntos

Androstadienos/química; Benzimidazóis/química; Inibidores Enzimáticos/química; Esteroide 21-Hidroxilase/química; Interações Medicamentosas; Humanos; Masculino; Simulação de Acoplamento Molecular; Neoplasias da Próstata/tratamento farmacológico

Palavras-chave

CYP21A2; corticosteroids; galeterone; galeterone metabolite; prostate cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Esteroide 21-Hidroxilase / Inibidores Enzimáticos / Androstadienos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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