Endothelial Dysfunction in Diabetic Retinopathy.
Front Endocrinol (Lausanne)
; 11: 591, 2020.
Article
em En
| MEDLINE
| ID: mdl-33013692
ABSTRACT
Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and receptors, pro-inflammatory cytokines and chemokines, proliferator-activated receptor-γ disruption, growth factors, oxidative stress, and microRNA. These factors promote retinal endothelial dysfunction, which results in the development of DR. In this review, we summarize the contributors in the pathophysiology of DR for a better understanding of the molecular and cellular mechanism in the development of DR with a special emphasis on retinal endothelial dysfunction.
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MEDLINE
Assunto principal:
Retina
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Endotélio Vascular
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Transdução de Sinais
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Estresse Oxidativo
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Retinopatia Diabética
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article