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Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-ß/Smad2/3 pathway intensification and antifibrotic TGF-ß/Smad1/5/(8)9 pathway impairment.
Wnuk, Dawid; Paw, Milena; Ryczek, Karolina; Bochenek, Grazyna; Sladek, Krzysztof; Madeja, Zbigniew; Michalik, Marta.
Afiliação
  • Wnuk D; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378, Kraków, Poland. dawid.wnuk@uj.edu.pl.
  • Paw M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378, Kraków, Poland.
  • Ryczek K; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378, Kraków, Poland.
  • Bochenek G; Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
  • Sladek K; Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
  • Madeja Z; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378, Kraków, Poland.
  • Michalik M; Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-378, Kraków, Poland. marta.michalik@uj.edu.pl.
Sci Rep ; 10(1): 16492, 2020 10 05.
Article em En | MEDLINE | ID: mdl-33020537
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Transdução de Sinais / Fator de Crescimento Transformador beta / Proteínas Smad Reguladas por Receptor / Miofibroblastos / Fibroblastos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Transdução de Sinais / Fator de Crescimento Transformador beta / Proteínas Smad Reguladas por Receptor / Miofibroblastos / Fibroblastos Idioma: En Ano de publicação: 2020 Tipo de documento: Article