An Important Dilemma: Fibrinolytic Treatment in Bleeding Diathesis.
Prehosp Disaster Med
; 35(6): 690-692, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33023694
ABSTRACT
Pulmonary embolism is a clinical condition with high mortality rates in all age groups. The treatment includes anticoagulation and fibrinolytic therapy, and clinical management is challenging in cases of bleeding diathesis. Sepsis-induced coagulopathy (SIC), which has been recently defined to cause disruption of coagulation cascade accompanied by organ dysfunctions, is regarded as a major cause of mortality. It is noteworthy that there is no decrease in fibrinogen levels, unlike disseminated intravascular coagulopathy (DIC). This study aimed to present the management of a 70-year-old female patient who was admitted to emergency department with atypical complaints and diagnosed with pulmonary embolism due to deep vein thrombosis and septic shock. The clinical success of fibrinolytic therapy following the administration of fresh frozen plasma (FFP), although the patient had elevated international normalized ratio (INR), is presented in this case report. Since elevated INR and thrombocytopenia, which are observed in SIC, are caused by the inhibition of fibrinolysis, fibrinolytic therapy can be a rational treatment choice considering the profit/loss rate.
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Base de dados:
MEDLINE
Assunto principal:
Embolia Pulmonar
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Choque Séptico
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Trombose Venosa
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Transtornos Hemorrágicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article