Filariasis of the breast caused by Brugia pahangi: A concomitant finding with invasive ductal carcinoma.
Parasitol Int
; 80: 102203, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33027710
ABSTRACT
Extralymphatic filariasis is an uncommon phenomenon that can be caused by several lymphatic filarial species, including zoonotic filaria of animal origins. In this study, we report a case of a 64-year-old Thai woman who presented with a lump in her left breast that was diagnosed with invasive ductal carcinoma. At the same time, a small nodule was found in her right breast, via imaging study, without any abnormal symptoms. A core needle biopsy of the right breast nodule revealed a filarial-like nematode compatible with the adult stage of Brugia sp. A molecular identification of the nematode partial mt 12rRNA gene and ITS1 suggested the causative species as closely related to Brugia pahangi, a zoonotic lymphatic filaria of animals such as cats and dogs. The sequence of the partial mt 12rRNA and ITS1 gene in this patient was 94% and 99% identical to the previously reported sequence of mt 12rRNA and ITS1 genes of B. pahangi. The sequence of ITS1 gene is 99% similar to B. pahangi microfilaria from infected dogs in Bangkok, which was highly suspected of having a zoonotic origin. As far as we know, this is the first case report of B. pahangi filariasis presented with a breast mass concomitantly found in a patient with invasive ductal carcinoma. This raised serious concern regarding the zoonotic transmission of filariasis from natural animal reservoirs.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Mamárias
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Neoplasias da Mama
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Brugia pahangi
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Carcinoma Ductal de Mama
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Filariose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article