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Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions.
Fujikura, Kohei; Hosoda, Waki; Felsenstein, Matthäus; Song, Qianqian; Reiter, Johannes G; Zheng, Lily; Beleva Guthrie, Violeta; Rincon, Natalia; Dal Molin, Marco; Dudley, Jonathan; Cohen, Joshua D; Wang, Pei; Fischer, Catherine G; Braxton, Alicia M; Noë, Michaël; Jongepier, Martine; Fernández-Del Castillo, Carlos; Mino-Kenudson, Mari; Schmidt, C Max; Yip-Schneider, Michele T; Lawlor, Rita T; Salvia, Roberto; Roberts, Nicholas J; Thompson, Elizabeth D; Karchin, Rachel; Lennon, Anne Marie; Jiao, Yuchen; Wood, Laura D.
Afiliação
  • Fujikura K; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hosoda W; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Felsenstein M; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.
  • Song Q; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Reiter JG; Department of Surgery, Charité Universitätsmedizin, Berlin, Germany.
  • Zheng L; State Key Lab of Molecular Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Beleva Guthrie V; Canary Center for Cancer Early Detection in Department of Radiology, Stanford Cancer Institute, and Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, USA.
  • Rincon N; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Dal Molin M; Personal Genome Diagnostics, Baltimore, Maryland, USA.
  • Dudley J; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Cohen JD; Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Wang P; Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Fischer CG; Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Braxton AM; State Key Lab of Molecular Oncology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Noë M; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Jongepier M; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Fernández-Del Castillo C; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Mino-Kenudson M; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Schmidt CM; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Yip-Schneider MT; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Lawlor RT; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Salvia R; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Roberts NJ; ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
  • Thompson ED; General and Pancreatic Surgery Department, The Pancreas Institute and Hospital Trust of Verona, Verona, Italy.
  • Karchin R; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Lennon AM; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Jiao Y; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
  • Wood LD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gut ; 70(5): 928-939, 2021 05.
Article em En | MEDLINE | ID: mdl-33028669
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Papilar / Adenocarcinoma Mucinoso / Sequenciamento do Exoma / Neoplasias Intraductais Pancreáticas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Papilar / Adenocarcinoma Mucinoso / Sequenciamento do Exoma / Neoplasias Intraductais Pancreáticas Idioma: En Ano de publicação: 2021 Tipo de documento: Article