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Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters.
Yuan, Shuofeng; Wang, Runming; Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Cheng, Tianfan; Chik, Kenn Ka-Heng; Ye, Zi-Wei; Wang, Suyu; Lee, Andrew Chak-Yiu; Jin, Lijian; Li, Hongyan; Jin, Dong-Yan; Yuen, Kwok-Yung; Sun, Hongzhe.
Afiliação
  • Yuan S; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Wang R; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Chan JF; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Zhang AJ; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China.
  • Cheng T; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Chik KK; Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Ye ZW; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Wang S; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Lee AC; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Jin L; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Li H; Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Jin DY; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Yuen KY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China.
  • Sun H; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Hong Kong, China. kyyuen@hku.hk.
Nat Microbiol ; 5(11): 1439-1448, 2020 11.
Article em En | MEDLINE | ID: mdl-33028965

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Pneumonia Viral / Ranitidina / Replicação Viral / Bismuto / Infecções por Coronavirus / Betacoronavirus Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Pneumonia Viral / Ranitidina / Replicação Viral / Bismuto / Infecções por Coronavirus / Betacoronavirus Idioma: En Ano de publicação: 2020 Tipo de documento: Article