A rare case of atypical spinal neurocytoma with EGFR mutation in a 12-year-old boy.
Childs Nerv Syst
; 37(7): 2399-2403, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33029729
ABSTRACT
Spinal neurocytoma (SN), although frequently reportedly as tumors of the central nervous system (CNS), are a distinct class of tumors, which can achieve a better prognosis following subtotal or gross total tumor resection. Nonetheless, even with the premise of successful treatment after tumor resection, poor prognosis after treatment due to the SN high proliferation index (typically known as atypical SN) have been reported. Over the past two decades, atypical SN was only reported in four pediatric cases, amidst the lingering controversy surrounding its postoperative adjuvant therapy. Thus, herein, we report a unique case of atypical SN with epidermal growth factor receptor (EGFR) amplification mutation in a 12-year-old boy. We, however, also highlighted the significance of radiotherapy and target therapy for patients with SN.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Neurocitoma
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article