Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells.
Bioorg Med Chem Lett
; 30(23): 127606, 2020 12 01.
Article
em En
| MEDLINE
| ID: mdl-33038547
ABSTRACT
The cAMP-response element (CRE) is critical in the formation of long-term memory. To prove the pharmacological effects of the methoxyflavones-rich residue (MRR) and its constituent methoxyflavones (1-9) extracted from the rhizomes of Kaempferia parviflora on the nervous system, we examined the effects of the MRR and methoxyflavones (1-9) on CRE-mediated transcription in PC12D cells. The MRR increased CRE-mediated transcription in PC12D cells. In addition, among methoxyflavones (1-9) isolated from MRR, compounds 1-4 increased CRE-mediated transcription. These results suggest that K. parviflora and methoxyflavone might be very useful materials for preventing and recovering from cognitive decline.
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MEDLINE
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Transcrição Gênica
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Zingiberaceae
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Flavonas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article