Suppression of up-regulated LXR&#945; by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism.

Xie, Ying; Feng, Sen-Ling; Mai, Chu-Tian; Zheng, Yan-Fang; Wang, Hui; Liu, Zhong-Qiu; Zhou, Hua; Liu, Liang

Suppression of up-regulated LXRα by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism.

Xie, Ying; Feng, Sen-Ling; Mai, Chu-Tian; Zheng, Yan-Fang; Wang, Hui; Liu, Zhong-Qiu; Zhou, Hua; Liu, Liang.

Afiliação

Xie Y; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR. Electronic address: yxie@must.edu.mo.
Feng SL; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR.
Mai CT; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR.
Zheng YF; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR.
Wang H; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR.
Liu ZQ; International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P. R. China.
Zhou H; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR.
Liu L; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR. Electronic address: Lliu@must.edu.mo.

Phytomedicine ; 80: 153339, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33038868

Assuntos

Artrite Experimental/tratamento farmacológico; Metabolismo dos Lipídeos/efeitos dos fármacos; Receptores X do Fígado/metabolismo; Silibina/farmacologia; Animais; Artrite Experimental/metabolismo; Artrite Reumatoide/tratamento farmacológico; Linhagem Celular; Citocinas/metabolismo; Dislipidemias/tratamento farmacológico; Enzimas/metabolismo; Regulação da Expressão Gênica/efeitos dos fármacos; Hepatócitos/efeitos dos fármacos; Humanos; Lipogênese/efeitos dos fármacos; Lipogênese/fisiologia; Fígado/efeitos dos fármacos; Fígado/metabolismo; Receptores X do Fígado/antagonistas & inibidores; Receptores X do Fígado/genética; Masculino; NF-kappa B/metabolismo; Ratos Sprague-Dawley; Regulação para Cima/efeitos dos fármacos

Palavras-chave

LXRα; Lipid metabolism; Lipogenesis enzymes; Rheumatoid arthritis; Silybin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Metabolismo dos Lipídeos / Receptores X do Fígado / Silibina Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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