Calhex231 ameliorates myocardial fibrosis post myocardial infarction in rats through the autophagy-NLRP3 inflammasome pathway in macrophages.

Liu, Wenxiu; Sun, Jiaxing; Guo, Yutong; Liu, Na; Ding, Xue; Zhang, Xin; Chi, Jinyu; Kang, Ningning; Liu, Yue; Yin, Xinhua

Liu, Wenxiu; Sun, Jiaxing; Guo, Yutong; Liu, Na; Ding, Xue; Zhang, Xin; Chi, Jinyu; Kang, Ningning; Liu, Yue; Yin, Xinhua.

Afiliação

Liu W; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Sun J; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Guo Y; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Liu N; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ding X; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhang X; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Chi J; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Kang N; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Liu Y; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yin X; Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.

J Cell Mol Med ; 24(22): 13440-13453, 2020 11.

Article em En | MEDLINE | ID: mdl-33043596

Assuntos

Benzamidas/farmacologia; Cardiomiopatias/etiologia; Cardiomiopatias/metabolismo; Cicloexilaminas/farmacologia; Inflamassomos/metabolismo; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Infarto do Miocárdio/complicações; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Animais; Autofagia/efeitos dos fármacos; Biomarcadores; Cardiomiopatias/patologia; Modelos Animais de Doenças; Fibrose; Imunofluorescência; Imuno-Histoquímica; Macrófagos Peritoneais/efeitos dos fármacos; Macrófagos Peritoneais/metabolismo; Masculino; Ratos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

NLRP3 inflammasome; autophagy; calcium-sensing receptor; macrophage; myocardial infarction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Cicloexilaminas / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos / Cardiomiopatias / Infarto do Miocárdio Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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