Convergent and Stereoselective Method for the Synthesis of Acyclic α-Chloroenamides.
J Org Chem
; 85(21): 14158-14165, 2020 11 06.
Article
em En
| MEDLINE
| ID: mdl-33045836
ABSTRACT
A direct, stereocontrolled synthesis of acyclic α-chloroenamides is presented. Our methodology showed good yields and substrate scope. Mechanistic insights are provided that account for the high levels of stereoselectivity reported. Subsequent synthetic manipulation of the α-chloroenamides provides direct entry to polyfunctionalized acyclic enamides, compounds of wide use in organic chemistry and the pharmaceutical industry.
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MEDLINE
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En
Ano de publicação:
2020
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Article